Released on a WHIM

Released on a WHIM.

studies with CLL and MCL have provided support for this explanation (Buchner et al11; M. F. M. de Rooij, J. J. Buggy, and M.S., manuscript in preparation). In this perspective, it is tempting to speculate that combining these agents with anti-CD47 may turn out to be a highly efficacious treatment for NHL patients: once the malignant B cells have been forced out of their protective growthand sur...

Chromothriptic Cure of WHIM Syndrome

Chromothripsis is a catastrophic cellular event recently described in cancer in which chromosomes undergo massive deletion and rearrangement. Here, we report a case in which chromothripsis spontaneously cured a patient with WHIM syndrome, an autosomal dominant combined immunodeficiency disease caused by gain-of-function mutation of the chemokine receptor CXCR4. In this patient, deletion of the ...

Studying the Whim with Gamma Ray Bursts

We assess the possibility to detect and characterize the physical state of the missing baryons at low redshift by analyzing the X-ray absorption spectra of the Gamma Ray Burst [GRB] afterglows, measured by a micro calorimeters-based detector with 3 eV resolution and 1000 cm effective area and capable of fast repointing, similar to that on board of the recently proposed X-ray satellites EDGE and...

Sex allocation: At the females' whim

Experimental studies of wild birds suggest that females have a previously unappreciated ability to control the sex ratio of their offspring in response to variation in sex-specific fitness benefits.

WHIM Syndrome (Warts Hyopogammaglobulinemia Infections Myelokhatexis)